| EldedaCliek | Дата: Понедельник, 02.09.2013, 00:48 | Сообщение # 1 |
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| Altering Calcium Build-Up In Blood Vessels - New Treatment for Atherosclerosis? Scientists from Seoul National University, South Korea, reported in PLoS Biology that they identified the cells responsible for creating calcium build-up in vessel walls, which eventually lead to atherosclerosis and heart disease. Hyo-Soo Kim and team explained that the system of calcium accumulation in blood vessels is not that different to what occurs during bone formation - it consists of maintaining a balance between osteoblasts (bone-producing cells) and osteoclasts (bone-eliminating cells). In their study the team categorized the starting point of a population of vascular-calcifying progenitor cells, and how likely they were to differentiate into different kinds of cells. Dr Kim explained We show that vascular calcifying progenitor cells in the artery have the potential to become either osteoblasts or osteoclasts.
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And a certain chemical can push these cells towards becoming osteoclasts, which leads to the softening of the blood vessels. The researchers organized the cells from mice aortas into two groups, both of which came from bone marrow and expressed Sca-1, a cell-surface protein. However, only one group expressed another surface protein - PDGFRa. Cells that expressed just Sca-1 could develop into osteoblasts or osteoclasts, while those that expressed both Sca-1 and PDGFRa only became osteoblasts.
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